3pg3 Summary


Human p38 MAP Kinase in Complex with RL182

A publication describing this structure is not available. The depositing authors are Gruetter, C.search; Simard, J.R.search; Getlik, M.search; Rauh, D.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Sequence family (Pfam)
A (Q16539) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch NFAT protein bindingsearch MAP kinase kinase activitysearch cellular response to DNA damage stimulussearch angiogenesissearch striated muscle cell differentiationsearch toll-like receptor 9 signaling pathwaysearch toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch response to stresssearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch activation of MAPK activitysearch toll-like receptor 4 signaling pathwaysearch signal transduction in response to DNA damagesearch blood coagulationsearch cell morphogenesissearch regulation of sequence-specific DNA binding transcription factor activitysearch MyD88-independent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch positive regulation of erythrocyte differentiationsearch cellular response to vascular endothelial growth factor stimulussearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch protein phosphorylationsearch positive regulation of myotube differentiationsearch regulation of transcription from RNA polymerase II promotersearch osteoclast differentiationsearch muscle cell differentiationsearch stress-activated MAPK cascadesearch p38MAPK cascadesearch fatty acid oxidationsearch gene expressionsearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cell surface receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch chondrocyte differentiationsearch intracellular signal transductionsearch signal transductionsearch regulation of transcription, DNA-templatedsearch positive regulation of protein import into nucleussearch cellular response to ionizing radiationsearch toll-like receptor 5 signaling pathwaysearch phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of myoblast differentiationsearch cellular component movementsearch lipopolysaccharide-mediated signaling pathwaysearch glucose metabolic processsearch skeletal muscle tissue developmentsearch 3'-UTR-mediated mRNA stabilizationsearch peptidyl-serine phosphorylationsearch positive regulation of blood vessel endothelial cell migrationsearch innate immune responsesearch mRNA metabolic processsearch DNA damage checkpointsearch response to lipopolysaccharidesearch chemotaxissearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch cellular response to lipopolysaccharidesearch response to muramyl dipeptidesearch RNA metabolic processsearch toll-like receptor 2 signaling pathwaysearch Ras protein signal transductionsearch platelet activationsearch toll-like receptor 10 signaling pathwaysearch cartilage condensationsearch myoblast differentiation involved in skeletal muscle regenerationsearch apoptotic processsearch nucleoplasmsearch cellsearch cytosolsearch cytoplasmsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch