X-ray crystal structure of compound 2a bound to human CHK1 kinase domain
The structure was published by Zhao, L., Zhang, Y., Dai, C., et al., Parry, D., Fischmann, T., and Siddiqui, M.A., in 2010 in a paper entitled "Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.59 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 273 residues which is < 90% of the natural sequence. Out of 273 residues 256 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: