3p5l Summary


Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate

The structure was published by Carta, F., Aggarwal, M., Maresca, A., Scozzafava, A., McKenna, R., and Supuran, C.T., in 2012 in a paper entitled "Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.498 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch extracellular spacesearch plasma membranesearch cytoplasmsearch myelin sheathsearch cytosolsearch apical part of cellsearch microvillussearch extracellular vesicular exosomesearch axonsearch basolateral plasma membranesearch membranesearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch bicarbonate transportsearch one-carbon metabolic processsearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch response to zinc ionsearch small molecule metabolic processsearch response to pHsearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch response to steroid hormonesearch positive regulation of cellular pH reductionsearch response to estrogensearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch