3p5a Summary


Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate

The structure was published by Carta, F., Aggarwal, M., Maresca, A., et al., McKenna, R., Masini, E., and Supuran, C.T., in 2012 in a paper entitled "Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.49 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch kidney developmentsearch secretionsearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch odontogenesis of dentin-containing toothsearch response to pHsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch one-carbon metabolic processsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch response to estrogensearch response to steroid hormonesearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch response to organic substancesearch response to zinc ionsearch regulation of anion transportsearch cytoplasmsearch basolateral plasma membranesearch apical part of cellsearch axonsearch cytosolsearch membranesearch extracellular spacesearch extracellular vesicular exosomesearch plasma membranesearch microvillussearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch