3p55 Summary


Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide

The structure was published by Salmon, A.J., Williams, M.L., Hofmann, A., and Poulsen, S.A., in 2012 in a paper entitled "Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch lyase activitysearch one-carbon metabolic processsearch angiotensin-activated signaling pathwaysearch kidney developmentsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch response to zinc ionsearch response to estrogensearch carbon dioxide transportsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch response to pHsearch secretionsearch extracellular vesicular exosomesearch cytosolsearch cytoplasmsearch plasma membranesearch membranesearch extracellular spacesearch basolateral plasma membranesearch apical part of cellsearch microvillussearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch