3p3j Summary


Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide

The structure was published by Salmon, A.J., Williams, M.L., Hofmann, A., and Poulsen, S.A., in 2012 in a paper entitled "Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch metal ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch cytosolsearch membranesearch plasma membranesearch basolateral plasma membranesearch apical part of cellsearch cytoplasmsearch myelin sheathsearch extracellular vesicular exosomesearch extracellular spacesearch microvillussearch axonsearch response to pHsearch response to zinc ionsearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch kidney developmentsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch one-carbon metabolic processsearch response to estrogensearch regulation of intracellular pHsearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch secretionsearch response to organic substancesearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch regulation of anion transportsearch positive regulation of bone resorptionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch