3p3h Summary


Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide

The structure was published by Salmon, A.J., Williams, M.L., Hofmann, A., and Poulsen, S.A., in 2012 in a paper entitled "Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 96% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch arylesterase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch plasma membranesearch cytosolsearch cytoplasmsearch myelin sheathsearch basolateral plasma membranesearch extracellular spacesearch membranesearch microvillussearch extracellular exosomesearch apical part of cellsearch axonsearch secretionsearch angiotensin-activated signaling pathwaysearch one-carbon metabolic processsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch response to estrogensearch positive regulation of cellular pH reductionsearch response to zinc ionsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch cellular response to fluid shear stresssearch small molecule metabolic processsearch kidney developmentsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch regulation of anion transportsearch regulation of chloride transportsearch response to pHsearch response to organic substancesearch positive regulation of bone resorptionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch