3p08 Summary

pdbe.org/3p08
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Crystal structure of the human BTK kinase domain

A publication describing this structure is not available. The depositing authors are Yu, C.L.search; Hymowitz, S.G.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase BTK.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase BTK Q06187 (393-659) (BTK_HUMAN)search Homo sapienssearch < 90% 267 96%
B Tyrosine-protein kinase BTK Q06187 (393-659) (BTK_HUMAN)search Homo sapienssearch < 90% 267 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q06187 (393 - 659) Tyrosine-protein kinase BTK Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q06187) protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch