3oys Summary


Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE

The structure was published by Hen, N., Bialer, M., Yagen, B., et al., McKenna, R., Scozzafava, A., and Supuran, C.T., in 2011 in a paper entitled "Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.538 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch one-carbon metabolic processsearch carbon dioxide transportsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch regulation of anion transportsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch bicarbonate transportsearch response to estrogensearch response to pHsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch secretionsearch response to zinc ionsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch kidney developmentsearch plasma membranesearch extracellular vesicular exosomesearch membranesearch microvillussearch apical part of cellsearch cytoplasmsearch cytosolsearch extracellular spacesearch basolateral plasma membranesearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch