3orl Summary

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Mycobacterium tuberculosis PknB kinase domain L33D mutant (crystal form 3)

The structure was published by Lombana, T.N., Echols, N., Good, M.C., et al., Falick, A.M., King, D.S., and Alber, T., in 2010 in a paper entitled "Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr kinase, PknB" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine protein kinase. This molecule has the UniProt identifier A5TY84 (A5TY84_MYCTA)search. The sample contained 311 residues which is < 90% of the natural sequence. Out of 311 residues 259 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine protein kinase A5TY84 (1-308) (A5TY84_MYCTA)search Mycobacterium tuberculosis H37Rasearch < 90% 311 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
A5TY84 (1 - 308) Serine/threonine protein kinase Mycobacterium tuberculosis H37Ra

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (A5TY84) protein phosphorylationsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch