› 3oq3

X-ray diffraction
2.1Å resolution

Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor

Released:
DOI: 10.2210/pdb3oq3/pdb
PDB entry 3oq3 coloured by chain, front view.
PDB entry 3oq3 coloured by chain, side view.
PDB entry 3oq3 coloured by chain, top view.
Source organisms:
Entry authors: Fremont DH, Lee CA, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139533 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon alpha-5 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 18.99 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P07349 (Residues: 24-189; Coverage: 100%)
Gene name: Ifna5
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;
Soluble interferon alpha/beta receptor OPG204 Chain: B
Molecule details ›
Chain: B
Length: 329 amino acids
Theoretical weight: 37.63 KDa
Source organism: Ectromelia virus Moscow
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JFS5 (Residues: 31-358; Coverage: 92%)
Gene names: C12R, EVI194, EVM1194, EVM4194, EVM5194, EVMK194
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

5 bound ligands:
Ligand ZN 1 x ZN
Ligand CL 1 x CL
Ligand EDO 4 x EDO
Ligand ACT 2 x ACT
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 48.84Å b: 75.9Å c: 182.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.235
Expression system: Escherichia coli

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