3oq1 Summary

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Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor

The structure was published by Yan, X., Wang, Z., Sudom, A., et al., Walker, N., Ye, Q., and Powers, J.P., in 2010 in a paper entitled "The synthesis and SAR of novel diarylsulfone 11beta-HSD1 inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Corticosteroid 11-beta-dehydrogenase isozyme 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Corticosteroid 11-beta-dehydrogenase isozyme 1 P28845 (24-292) (DHI1_HUMAN)search Homo sapienssearch 90% 286 94%
B Corticosteroid 11-beta-dehydrogenase isozyme 1 P28845 (24-292) (DHI1_HUMAN)search Homo sapienssearch 90% 286 94%
C Corticosteroid 11-beta-dehydrogenase isozyme 1 P28845 (24-292) (DHI1_HUMAN)search Homo sapienssearch 90% 286 94%
D Corticosteroid 11-beta-dehydrogenase isozyme 1 P28845 (24-292) (DHI1_HUMAN)search Homo sapienssearch 90% 286 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28845 (24 - 292) Corticosteroid 11-beta-dehydrogenase isozyme 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P28845) NAD(P)-binding Rossmann-like Domainsearch PF00106: short chain dehydrogenasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D (P28845) endoplasmic reticulumsearch membranesearch integral component of membranesearch endoplasmic reticulum membranesearch oxidoreductase activitysearch 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activitysearch 11-beta-hydroxysteroid dehydrogenase (NADP+) activitysearch oxidation-reduction processsearch metabolic processsearch lipid metabolic processsearch steroid metabolic processsearch lung developmentsearch glucocorticoid biosynthetic processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, B, C, D Short-chain dehydrogenase/reductase SDRsearch Glucose/ribitol dehydrogenasesearch NAD(P)-binding domainsearch Short-chain dehydrogenase/reductase, conserved sitesearch