Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor
The structure was published by Yan, X., Wang, Z., Sudom, A., et al., Walker, N., Ye, Q., and Powers, J.P., in 2010 in a paper entitled "The synthesis and SAR of novel diarylsulfone 11beta-HSD1 inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Corticosteroid 11-beta-dehydrogenase isozyme 1.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: