3op0 Summary

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Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide

A publication describing this structure is not available. The depositing authors are Chaikuad, A.search; Guo, K.search; Cooper, C.D.O.search; Ayinampudi, V.search; Krojer, T.search; Ugochukwu, E.search; Muniz, J.R.C.search; Vollmar, M.search; Canning, P.search; von Delft, F.search; Arrowsmith, C.H.search; Weigelt, J.search; Edwards, A.M.search; Bountra, C.search; Bullock, A.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.52 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Signal transduction protein CBL-C and Epidermal growth factor receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Signal transduction protein CBL-C Q9ULV8 (9-323) (CBLC_HUMAN)search Homo sapienssearch < 90% 323 99%
B Signal transduction protein CBL-C Q9ULV8 (9-323) (CBLC_HUMAN)search Homo sapienssearch < 90% 323 99%
C Epidermal growth factor receptor P00533 (1066-1076) (EGFR_HUMAN)search Homo sapienssearch < 90% 11 90%
D Epidermal growth factor receptor P00533 (1066-1076) (EGFR_HUMAN)search Homo sapienssearch < 90% 11 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9ULV8 (9 - 323) Signal transduction protein CBL-C Homo sapiens
P00533 (1066 - 1076) Epidermal growth factor receptor Homo sapiens

Chain Sequence family (Pfam)
A, B CBL proto-oncogene N-terminal domain 1search, CBL proto-oncogene N-terminus, EF hand-like domainsearch, CBL proto-oncogene N-terminus, SH2-like domainsearch
C, D

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q9ULV8) regulation of signalingsearch cell surface receptor signaling pathwaysearch calcium ion bindingsearch phosphotyrosine bindingsearch ubiquitin-protein transferase activitysearch signal transducer activitysearch nucleussearch

Chain InterPro annotation
A, B SH2 domainsearch Adaptor protein Cbl, N-terminal helicalsearch EF-hand domain pairsearch Adaptor protein Cbl, EF hand-likesearch Adaptor protein Cbl, SH2-likesearch Adaptor protein Cbl, PTB domainsearch Adaptor protein Cblsearch
C, D