3oom Summary


Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507

A publication describing this structure is not available. The depositing authors are Chaikuad, A.search; Sanvitale, C.search; Cooper, C.search; Mahajan, P.search; Daga, N.search; Petrie, K.search; Alfano, I.search; Gileadi, O.search; Fedorov, O.search; Allerston, C.search; Krojer, T.search; von Delft, F.search; Weigelt, J.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bountra, C.search; Bullock, A.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Activin receptor type-1. This molecule has the UniProt identifier Q04771 (ACVR1_HUMAN)search. The sample contained 301 residues which is < 90% of the natural sequence. Out of 301 residues 295 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Activin receptor type-1 Q04771 (201-499) (ACVR1_HUMAN)search Homo sapienssearch < 90% 301 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q04771 (201 - 499) Activin receptor type-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Transforming growth factor beta type I GS-motifsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q04771) protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch protein serine/threonine kinase activitysearch ATP bindingsearch receptor signaling protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch membranesearch

Chain InterPro annotation
A Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch