Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
A publication describing this structure is not available. The depositing authors are Chaikuad, A.; Sanvitale, C.; Cooper, C.; Mahajan, P.; Daga, N.; Petrie, K.; Alfano, I.; Gileadi, O.; Fedorov, O.; Allerston, C.; Krojer, T.; von Delft, F.; Weigelt, J.; Arrowsmith, C.H.; Edwards, A.M.; Bountra, C.; Bullock, A.; Structural Genomics Consortium (SGC)
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Activin receptor type-1. This molecule has the UniProt identifier Q04771 (ACVR1_HUMAN). The sample contained 301 residues which is < 90% of the natural sequence. Out of 301 residues 295 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: