3ona Summary

pdbe.org/3ona
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The SECRET domain in complex with CX3CL1

The structure was published by Xue, X.G., Lu, Q.Y., Wei, H., et al., Huang, L., Wang, H.Z., and Wang, X.Q., in 2011 in a paper entitled "Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tumour necrosis factor receptor and CX3CL1 protein.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumour necrosis factor receptor Q7TDW8 (162-320) (Q7TDW8_9POXV)search Ectromelia virussearch < 90% 163 96%
B CX3CL1 protein P78423 (24-100) (X3CL1_HUMAN)search Homo sapienssearch < 90% 80 82%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q7TDW8 (162 - 320) Tumour necrosis factor receptor Ectromelia virus
P78423 (24 - 100) CX3CL1 protein Homo sapiens

Chain Sequence family (Pfam)
A Protein of unknown function (DUF1406)search
B Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
B (P78423) chemokine activitysearch extracellular regionsearch membranesearch immune responsesearch

Chain InterPro annotation
A Poxvirus, TNF receptor-II, C-terminalsearch
B Chemokine interleukin-8-like domainsearch CX3C chemokine ligand 1search