3ona Summary


The SECRET domain in complex with CX3CL1

The structure was published by Xue, X.G., Lu, Q.Y., Wei, H., et al., Huang, L., Wang, H.Z., and Wang, X.Q., in 2011 in a paper entitled "Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tumour necrosis factor receptor and CX3CL1 protein.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumour necrosis factor receptor Q7TDW8 (162-320) (Q7TDW8_9POXV)search Ectromelia virussearch < 90% 163 96%
B CX3CL1 protein P78423 (24-100) (X3CL1_HUMAN)search Homo sapienssearch < 90% 80 82%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q7TDW8 (162 - 320) Tumour necrosis factor receptor Ectromelia virus
P78423 (24 - 100) CX3CL1 protein Homo sapiens

Chain Sequence family (Pfam)
A Protein of unknown function (DUF1406)search
B Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
B (P78423) chemokine activitysearch extracellular regionsearch membranesearch immune responsesearch

Chain InterPro annotation
A Poxvirus, TNF receptor-II, C-terminalsearch
B Chemokine interleukin-8-like domainsearch CX3C chemokine ligand 1search