3omv Summary


PDB entry 3omv (supersedes 3lb7)

Crystal structure of c-raf (raf-1)

The structure was published by Hatzivassiliou, G., Song, K., Yen, I., et al., Belvin, M., Friedman, L.S., and Malek, S., in 2010 in a paper entitled "RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of RAF proto-oncogene serine/threonine-protein kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RAF proto-oncogene serine/threonine-protein kinase P04049 (323-618) (RAF1_HUMAN)search Homo sapienssearch < 90% 307 85%
B RAF proto-oncogene serine/threonine-protein kinase P04049 (323-618) (RAF1_HUMAN)search Homo sapienssearch < 90% 307 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04049 (323 - 618) RAF proto-oncogene serine/threonine-protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P04049) protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch