Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Membrane attack complex component/perforin/complement C9
- Thrombospondin type-1 (TSP1) repeat
- Low-density lipoprotein (LDL) receptor class A repeat
- Thrombospondin type-1 (TSP1) repeat superfamily
- Membrane attack complex component/perforin (MACPF) domain
- Alpha-1-microglobulin
- LDL receptor-like superfamily
- Calycin
6 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Complement C8 (preferred)
PDBe Complex ID:
PDB-CPX-139558 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement component C8 alpha chain
Molecule details ›
Chain: A
Length: 554 amino acids
Theoretical weight: 61.78 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 554 amino acids
Theoretical weight: 61.78 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P07357 (Residues: 31-584; Coverage: 98%)
Sequence domains:
Complement component C8 beta chain
Molecule details ›
Chain: B
Length: 537 amino acids
Theoretical weight: 61.2 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 537 amino acids
Theoretical weight: 61.2 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P07358 (Residues: 55-591; Coverage: 96%)
Sequence domains:
Complement component C8 gamma chain
Molecule details ›
Chain: C
Length: 182 amino acids
Theoretical weight: 20.41 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin
Length: 182 amino acids
Theoretical weight: 20.41 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P07360 (Residues: 21-202; Coverage: 100%)
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin
