3oim Summary


Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate

The structure was published by Sippel, K.H., Stander, B.A., Robbins, A.H., et al., Silverman, D.N., Joubert, A.M., and McKenna, R., in 2011 in a paper entitled "Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of anion transportsearch response to pHsearch regulation of intracellular pHsearch response to organic substancesearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch positive regulation of cellular pH reductionsearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch response to estrogensearch kidney developmentsearch secretionsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch microvillussearch cytosolsearch apical part of cellsearch plasma membranesearch cytoplasmsearch basolateral plasma membranesearch extracellular vesicular exosomesearch extracellular spacesearch membranesearch myelin sheathsearch axonsearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch