3oik Summary


Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate

The structure was published by Sippel, K.H., Stander, B.A., Robbins, A.H., et al., Silverman, D.N., Joubert, A.M., and McKenna, R., in 2011 in a paper entitled "Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) regulation of anion transportsearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch response to estrogensearch odontogenesis of dentin-containing toothsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch response to pHsearch positive regulation of bone resorptionsearch response to zinc ionsearch morphogenesis of an epitheliumsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch small molecule metabolic processsearch one-carbon metabolic processsearch kidney developmentsearch secretionsearch response to organic substancesearch regulation of chloride transportsearch lyase activitysearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch metal ion bindingsearch cytosolsearch plasma membranesearch extracellular spacesearch extracellular vesicular exosomesearch microvillussearch axonsearch myelin sheathsearch apical part of cellsearch cytoplasmsearch basolateral plasma membranesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch