3og7 Summary


B-Raf Kinase V600E oncogenic mutant in complex with PLX4032

The structure was published by Bollag, G., Hirth, P., Tsai, J., et al., Xu, X., Nathanson, K.L., and Nolop, K., in 2010 in a paper entitled "Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of AKAP9-BRAF fusion protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AKAP9-BRAF fusion protein P15056 (448-720) (BRAF_HUMAN)search Homo sapienssearch < 90% 289 87%
B AKAP9-BRAF fusion protein P15056 (448-720) (BRAF_HUMAN)search Homo sapienssearch < 90% 289 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (448 - 720) AKAP9-BRAF fusion protein Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P15056) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch