3ocs Summary

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Crystal structure of bruton's tyrosine kinase in complex with inhibitor CGI1746

A publication describing this structure is not available. The depositing authors are Davies, D.R.search; Gallion, S.L.search; Staker, B.L.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase BTK. This molecule has the UniProt identifier Q06187 (BTK_HUMAN)search. The sample contained 271 residues which is < 90% of the natural sequence. Out of 271 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase BTK Q06187 (393-656) (BTK_HUMAN)search Homo sapienssearch < 90% 271 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q06187 (393 - 656) Tyrosine-protein kinase BTK Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch