3obj Summary


Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding

A publication describing this structure is not available. The depositing authors are Namboodiri, H.V.search; Karpusas, M.search; Bukhtiyarova, M.search; Springman, E.B.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 331 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q16539) MAP kinase activitysearch ATP bindingsearch protein bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch NFAT protein bindingsearch MAP kinase kinase activitysearch nucleotide bindingsearch transferase activitysearch cytosolsearch nucleoplasmsearch nucleussearch cytoplasmsearch cellsearch spindle polesearch extracellular vesicular exosomesearch mitochondrionsearch activation of MAPK activitysearch positive regulation of erythrocyte differentiationsearch positive regulation of myoblast fusionsearch peptidyl-serine phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch vascular endothelial growth factor receptor signaling pathwaysearch signal transductionsearch toll-like receptor 10 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch cell morphogenesissearch Ras protein signal transductionsearch platelet activationsearch regulation of sequence-specific DNA binding transcription factor activitysearch protein phosphorylationsearch response to stresssearch chemotaxissearch angiogenesissearch positive regulation of blood vessel endothelial cell migrationsearch cartilage condensationsearch osteoclast differentiationsearch RNA metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch intracellular signal transductionsearch toll-like receptor 2 signaling pathwaysearch positive regulation of protein import into nucleussearch striated muscle cell differentiationsearch stress-induced premature senescencesearch stress-activated MAPK cascadesearch toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch positive regulation of myotube differentiationsearch toll-like receptor 9 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch DNA damage checkpointsearch cellular response to DNA damage stimulussearch cellular component movementsearch regulation of transcription, DNA-templatedsearch fatty acid oxidationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch transcription, DNA-templatedsearch muscle cell differentiationsearch toll-like receptor 3 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch innate immune responsesearch neurotrophin TRK receptor signaling pathwaysearch gene expressionsearch positive regulation of myoblast differentiationsearch positive regulation of muscle cell differentiationsearch cellular response to ionizing radiationsearch chondrocyte differentiationsearch mRNA metabolic processsearch skeletal muscle tissue developmentsearch 3'-UTR-mediated mRNA stabilizationsearch p38MAPK cascadesearch response to muramyl dipeptidesearch apoptotic processsearch lipopolysaccharide-mediated signaling pathwaysearch signal transduction in response to DNA damagesearch cell surface receptor signaling pathwaysearch blood coagulationsearch response to lipopolysaccharidesearch glucose metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to lipopolysaccharidesearch phosphorylationsearch toll-like receptor 5 signaling pathwaysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch