3oaa Summary

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Structure of the E.coli F1-ATP synthase inhibited by subunit Epsilon

A publication describing this structure is not available. The depositing authors are Cingolani, G.search; Duncan, T.M.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.26 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This entry contains 102 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
B ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
C ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
I ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
J ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
K ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
Q ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
R ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
S ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
Y ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
Z ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
a ATP synthase subunit alpha P0ABB0 (1-513) (ATPA_ECOLI)search Escherichia coli K-12search 100% 513 95%
D ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
E ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
F ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
L ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
M ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
N ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
T ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
U ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
V ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
b ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
c ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
d ATP synthase subunit beta P0ABB4 (2-460) (ATPB_ECOLI)search Escherichia coli K-12search 100% 459 99%
G ATP synthase gamma chain P0ABA6 (2-287) (ATPG_ECOLI)search Escherichia coli K-12search 100% 286 99%
O ATP synthase gamma chain P0ABA6 (2-287) (ATPG_ECOLI)search Escherichia coli K-12search 100% 286 99%
W ATP synthase gamma chain P0ABA6 (2-287) (ATPG_ECOLI)search Escherichia coli K-12search 100% 286 99%
e ATP synthase gamma chain P0ABA6 (2-287) (ATPG_ECOLI)search Escherichia coli K-12search 100% 286 99%
H ATP synthase epsilon chain P0A6E6 (2-139) (ATPE_ECOLI)search Escherichia coli K-12search 98% 138 100%
P ATP synthase epsilon chain P0A6E6 (2-139) (ATPE_ECOLI)search Escherichia coli K-12search 98% 138 100%
X ATP synthase epsilon chain P0A6E6 (2-139) (ATPE_ECOLI)search Escherichia coli K-12search 98% 138 100%
f ATP synthase epsilon chain P0A6E6 (2-139) (ATPE_ECOLI)search Escherichia coli K-12search 98% 138 100%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P0ABB0 (1 - 513) ATP synthase subunit alpha Escherichia coli DH1
P0ABB4 (2 - 460) ATP synthase subunit beta Escherichia coli DH1
P0ABA6 (2 - 287) ATP synthase gamma chain Escherichia coli DH1
P0A6E6 (2 - 139) ATP synthase epsilon chain Escherichia coli DH1

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, I, J, K, Q, R, S, Y, Z, a (P0ABB0) Elongation Factor Tu (Ef-tu); domain 3search, P-loop containing nucleotide triphosphate hydrolasessearch, Lysinsearch PF00006: ATP synthase alpha/beta family, nucleotide-binding domainsearch, PF00306: ATP synthase alpha/beta chain, C terminal domainsearch, PF09378: HAS barrel domainsearch
D, E, F, L, M, N, T, U, V, b, c, d (P0ABB4) PF00006: ATP synthase alpha/beta family, nucleotide-binding domainsearch, PF00306: ATP synthase alpha/beta chain, C terminal domainsearch, PF02874: ATP synthase alpha/beta family, beta-barrel domainsearch
G, O, W, e (P0ABA6) PF00231: ATP synthasesearch
H, P, X, f (P0A6E6) PF00401: ATP synthase, Delta/Epsilon chain, long alpha-helix domainsearch, PF02823: ATP synthase, Delta/Epsilon chain, beta-sandwich domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, I, J, K, Q, R, S, Y, Z, a (P0ABB0) proton transportsearch ATP synthesis coupled proton transportsearch ATP hydrolysis coupled proton transportsearch ATP metabolic processsearch plasma membrane ATP synthesis coupled proton transportsearch ATP biosynthetic processsearch ion transportsearch transportsearch proton-transporting two-sector ATPase complex, catalytic domainsearch proton-transporting ATP synthase complex, catalytic core F(1)search plasma membranesearch membranesearch ATP bindingsearch hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancessearch proton-transporting ATP synthase activity, rotational mechanismsearch proton-transporting ATPase activity, rotational mechanismsearch protein bindingsearch hydrolase activitysearch nucleotide bindingsearch nucleoside-triphosphatase activitysearch
D, E, F, L, M, N, T, U, V, b, c, d (P0ABB4) ATP metabolic processsearch transportsearch ATP biosynthetic processsearch proton transportsearch ion transportsearch plasma membrane ATP synthesis coupled proton transportsearch ATP synthesis coupled proton transportsearch ATP hydrolysis coupled proton transportsearch proton-transporting two-sector ATPase complex, catalytic domainsearch proton-transporting ATP synthase complex, catalytic core F(1)search membranesearch plasma membranesearch nucleoside-triphosphatase activitysearch ATP bindingsearch hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancessearch proton-transporting ATPase activity, rotational mechanismsearch protein bindingsearch nucleotide bindingsearch proton-transporting ATP synthase activity, rotational mechanismsearch hydrolase activitysearch
G, O, W, e (P0ABA6) ATP synthesis coupled proton transportsearch transportsearch plasma membrane ATP synthesis coupled proton transportsearch ATP biosynthetic processsearch proton transportsearch ion transportsearch proton-transporting ATP synthase complex, catalytic core F(1)search plasma membranesearch membranesearch proton-transporting ATP synthase activity, rotational mechanismsearch protein bindingsearch proton-transporting ATPase activity, rotational mechanismsearch ATP bindingsearch
H, P, X, f (P0A6E6) ATP synthesis coupled proton transportsearch plasma membrane ATP synthesis coupled proton transportsearch ion transportsearch transportsearch ATP biosynthetic processsearch proton transportsearch proton-transporting ATP synthase complex, catalytic core F(1)search plasma membranesearch membranesearch proton-transporting ATPase activity, rotational mechanismsearch protein bindingsearch proton-transporting ATP synthase activity, rotational mechanismsearch ATP bindingsearch

Chain InterPro annotation
A, B, C, I, J, K, Q, R, S, Y, Z, a ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainsearch ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminalsearch ATPase, F1 complex alpha/beta subunit, N-terminal domainsearch ATPase, F1 complex, alpha subunitsearch HerA-ATP synthase, barrel domainsearch ATPase, alpha/beta subunit, nucleotide-binding domain, active sitesearch ATP synthase subunit alpha-like domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
D, E, F, L, M, N, T, U, V, b, c, d ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainsearch ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminalsearch AAA+ ATPase domainsearch ATPase, F1 complex alpha/beta subunit, N-terminal domainsearch ATPase, F1 complex, beta subunitsearch ATPase, alpha/beta subunit, nucleotide-binding domain, active sitesearch ATPase, F1 complex beta subunit/V1 complex, C-terminalsearch P-loop containing nucleoside triphosphate hydrolasesearch
G, O, W, e ATPase, F1 complex, gamma subunitsearch ATPase, F1 complex, gamma subunit conserved sitesearch ATPase, F1 complex, gamma subunit domainsearch
H, P, X, f ATPase, F1 complex, delta/epsilon subunitsearch ATPase, F1 complex, delta/epsilon subunit, N-terminalsearch ATPase, F1 complex, delta/epsilon subunit, C-terminal domainsearch