3o8u Summary


Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding

A publication describing this structure is not available. The depositing authors are Namboodiri, H.V.search; Karpusas, M.search; Bukhtiyarova, M.search; Springman, E.B.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 331 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q16539) protein phosphorylationsearch cellular response to lipopolysaccharidesearch toll-like receptor 4 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch cellular response to DNA damage stimulussearch positive regulation of myoblast differentiationsearch signal transductionsearch toll-like receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch skeletal muscle tissue developmentsearch fatty acid oxidationsearch positive regulation of reactive oxygen species metabolic processsearch cellular component movementsearch RNA metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch stress-activated MAPK cascadesearch positive regulation of protein import into nucleussearch osteoclast differentiationsearch platelet activationsearch positive regulation of myoblast fusionsearch chondrocyte differentiationsearch regulation of transcription from RNA polymerase II promotersearch angiogenesissearch positive regulation of transcription from RNA polymerase II promotersearch response to muramyl dipeptidesearch cellular response to ionizing radiationsearch positive regulation of blood vessel endothelial cell migrationsearch cell surface receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch apoptotic processsearch positive regulation of muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch p38MAPK cascadesearch 3'-UTR-mediated mRNA stabilizationsearch toll-like receptor 9 signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch gene expressionsearch vascular endothelial growth factor receptor signaling pathwaysearch cartilage condensationsearch regulation of transcription, DNA-templatedsearch positive regulation of myotube differentiationsearch striated muscle cell differentiationsearch glucose metabolic processsearch transcription, DNA-templatedsearch cell morphogenesissearch peptidyl-serine phosphorylationsearch signal transduction in response to DNA damagesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch phosphorylationsearch mRNA metabolic processsearch blood coagulationsearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch activation of MAPK activitysearch Ras protein signal transductionsearch intracellular signal transductionsearch toll-like receptor 10 signaling pathwaysearch chemotaxissearch response to stresssearch stress-induced premature senescencesearch toll-like receptor 2 signaling pathwaysearch response to lipopolysaccharidesearch muscle cell differentiationsearch innate immune responsesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch DNA damage checkpointsearch positive regulation of erythrocyte differentiationsearch nucleoplasmsearch nucleussearch cytosolsearch cytoplasmsearch mitochondrionsearch spindle polesearch extracellular vesicular exosomesearch cellsearch kinase activitysearch transferase activitysearch protein bindingsearch nucleotide bindingsearch MAP kinase kinase activitysearch ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch