3o7l Summary

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Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex

The structure was published by Masterson, L.R., Cheng, C., Yu, T., et al., Kornev, A., Taylor, S.S., and Veglia, G., in 2010 in a paper entitled "Dynamics connect substrate recognition to catalysis in protein kinase A." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely cAMP-dependent protein kinase catalytic subunit alpha and Cardiac phospholamban.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B cAMP-dependent protein kinase catalytic subunit alpha P05132 (2-351) (KAPCA_MOUSE)search Mus musculussearch 96% 350 93%
D cAMP-dependent protein kinase catalytic subunit alpha P05132 (2-351) (KAPCA_MOUSE)search Mus musculussearch 96% 350 95%
I Cardiac phospholamban P61014 (4-18) (PPLA_MOUSE)search Mus musculussearch < 90% 15 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P05132 (2 - 351) cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
P61014 (4 - 18) Cardiac phospholamban

Chain Structural classification (CATH) Sequence family (Pfam)
B (P05132) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
D (P05132) PF00069: Protein kinase domainsearch
I (P61014) PF04272: Phospholambansearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
B (P05132) regulation of osteoblast differentiationsearch protein phosphorylationsearch protein autophosphorylationsearch regulation of proteasomal protein catabolic processsearch regulation of tight junction assemblysearch cellular response to parathyroid hormone stimulussearch mesoderm formationsearch regulation of synaptic transmissionsearch sperm capacitationsearch cellular response to glucose stimulussearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch positive regulation of cell cycle arrestsearch peptidyl-threonine phosphorylationsearch positive regulation of protein export from nucleussearch neural tube closuresearch regulation of protein processingsearch phosphorylationsearch peptidyl-serine phosphorylationsearch cytoplasmsearch mitochondrionsearch sperm midpiecesearch nucleussearch plasma membranesearch AMP-activated protein kinase complexsearch cytosolsearch centrosomesearch neuromuscular junctionsearch membranesearch cell projectionsearch motile ciliumsearch ciliary basesearch ciliumsearch nucleoplasmsearch extracellular vesicular exosomesearch transferase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch nucleotide bindingsearch ATP bindingsearch protein kinase A regulatory subunit bindingsearch cAMP-dependent protein kinase activitysearch protein bindingsearch kinase activitysearch protein serine/threonine/tyrosine kinase activitysearch protein kinase bindingsearch ubiquitin protein ligase bindingsearch transferase activity, transferring phosphorus-containing groupssearch
D (P05132) protein phosphorylationsearch regulation of tight junction assemblysearch cellular response to glucose stimulussearch peptidyl-threonine phosphorylationsearch sperm capacitationsearch positive regulation of cell cycle arrestsearch peptidyl-serine phosphorylationsearch regulation of osteoblast differentiationsearch mesoderm formationsearch cellular response to parathyroid hormone stimulussearch regulation of synaptic transmissionsearch neural tube closuresearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch protein autophosphorylationsearch regulation of protein processingsearch phosphorylationsearch positive regulation of protein export from nucleussearch regulation of proteasomal protein catabolic processsearch plasma membranesearch neuromuscular junctionsearch ciliumsearch cytoplasmsearch motile ciliumsearch nucleussearch mitochondrionsearch nucleoplasmsearch sperm midpiecesearch ciliary basesearch centrosomesearch AMP-activated protein kinase complexsearch membranesearch cell projectionsearch cytosolsearch extracellular vesicular exosomesearch protein serine/threonine kinase activitysearch protein serine/threonine/tyrosine kinase activitysearch ubiquitin protein ligase bindingsearch transferase activitysearch protein bindingsearch ATP bindingsearch cAMP-dependent protein kinase activitysearch nucleotide bindingsearch protein kinase bindingsearch kinase activitysearch protein kinase activitysearch protein kinase A regulatory subunit bindingsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
D Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I Phospholambansearch