3o5z Summary

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Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)

The structure was published by Chen, S., Xiao, Y., Ponnusamy, R., Tan, J., Lei, J., and Hilgenfeld, R., in 2011 in a paper entitled "X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.01 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Phosphatidylinositol 3-kinase regulatory subunit beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphatidylinositol 3-kinase regulatory subunit beta O00459 (1-85) (P85B_HUMAN)search Homo sapienssearch < 90% 90 91%
B Phosphatidylinositol 3-kinase regulatory subunit beta O00459 (1-85) (P85B_HUMAN)search Homo sapienssearch < 90% 90 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O00459 (1 - 85) Phosphatidylinositol 3-kinase regulatory subunit beta Homo sapiens

Chain ID Molecular function (GO) Cellular component (GO)
A, B (O00459) phosphatidylinositol 3-kinase regulator activitysearch phosphatidylinositol 3-kinase complexsearch

Chain InterPro annotation
A, B SH3 domainsearch PI3 kinase, P85 regulatory subunitsearch