3o5x Summary


PDB entry 3o5x (supersedes 3jrl)

Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor

The structure was published by Zhang, X., He, Y., Liu, S., et al., Wang, L., Chan, R.J., and Zhang, Z.Y., in 2010 in a paper entitled "Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein phosphatase non-receptor type 11. This molecule has the UniProt identifier Q06124 (PTN11_HUMAN)search. The sample contained 276 residues which is < 90% of the natural sequence. Out of 276 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein phosphatase non-receptor type 11 Q06124 (262-532) (PTN11_HUMAN)search Homo sapienssearch 90% 276 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q06124 (262 - 532) Tyrosine-protein phosphatase non-receptor type 11 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q06124) Protein tyrosine phosphatase superfamilysearch PF00102: Protein-tyrosine phosphatasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q06124) phosphatase activitysearch protein tyrosine phosphatase activitysearch dephosphorylationsearch protein dephosphorylationsearch

Chain InterPro annotation
A Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch