PDB entry 3o5x (supersedes 3jrl)
Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor
The structure was published by Zhang, X., He, Y., Liu, S., et al., Wang, L., Chan, R.J., and Zhang, Z.Y., in 2010 in a paper entitled "Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein phosphatase non-receptor type 11. This molecule has the UniProt identifier Q06124 (PTN11_HUMAN). The sample contained 276 residues which is < 90% of the natural sequence. Out of 276 residues 254 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: