3o51 Summary

pdbe.org/3o51
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Crystal structure of anthranilamide 10 bound to AuroraA

The structure was published by Cee, V.J., Schenkel, L.B., Hodous, B.L., et al., Zhao, H., Payton, M., and Geuns-Meyer, S.D., in 2010 in a paper entitled "Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6. This molecule has the UniProt identifier O14965 (AURKA_HUMAN)search. The sample contained 267 residues which is < 90% of the natural sequence. Out of 267 residues 240 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 267 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (125 - 391) cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14965) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch