Crystal structure of anthranilamide 10 bound to AuroraA
The structure was published by Cee, V.J., Schenkel, L.B., Hodous, B.L., et al., Zhao, H., Payton, M., and Geuns-Meyer, S.D., in 2010 in a paper entitled "Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6. This molecule has the UniProt identifier O14965 (AURKA_HUMAN). The sample contained 267 residues which is < 90% of the natural sequence. Out of 267 residues 240 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: