3o50 Summary

pdbe.org/3o50
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Crystal structure of benzamide 9 bound to AuroraA

The structure was published by Cee, V.J., Schenkel, L.B., Hodous, B.L., et al., Zhao, H., Payton, M., and Geuns-Meyer, S.D., in 2010 in a paper entitled "Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 267 93%
B cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 O14965 (125-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 267 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (125 - 391) cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O14965) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch