PDB 3o50 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Aurora kinase A
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Multimeric state: monomeric

Accessible surface area: 12288.61 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-127232

$Monomeric assembly 1 of PDB entry 3o50 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 3o50 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 3o50 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Aurora kinase A
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Multimeric state: monomeric

Accessible surface area: 12731.3 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-127232

$Monomeric assembly 2 of PDB entry 3o50 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 3o50 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 3o50 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Aurora kinase A;</li> <li class='image_legend_li'>1 copy of N-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Aurora kinase A

Chains: A, B
Length: 267 amino acids
Theoretical weight: 31.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: O14965 (Residues: 125-391; Coverage: 66%)

Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Pfam: Protein kinase domain
InterPro:

Aurora kinase-like
Protein kinase-like domain superfamily
Aurora kinase A
Protein kinase domain
Protein kinase, ATP binding site
Serine/threonine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

Aurora kinase A in PDB entry 3o50, assembly 1, front view.

Aurora kinase A in PDB entry 3o50, assembly 1, side view.

Aurora kinase A in PDB entry 3o50, assembly 1, top view.

FASTA Sequence


    >pdb|3o50|A B

KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPS

PDBe-KB: UniProt Coverage View: O14965

Molecule details ›

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FASTA (Protein chains A, B)
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Updated mmCIF file
PDB file
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PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST O14965 (UniProt)

Protein Data Bank in Europe

Crystal structure of benzamide 9 bound to AuroraA

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 3o50 › Structure analysis

Crystal structure of benzamide 9 bound to AuroraA

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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3o50 › Structure analysis