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Crystal Structure of the Vibrio cholerae Cytolysin (HlyA) Heptameric Pore

Source organism: Vibrio cholerae 12129(1)
Biochemical function: not assigned
Biological process: cytolysis in another organism
Cellular component: extracellular region

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF16458
Domain description: Beta-prism lectin
Occurring in:
  1. Hemolysin
The deposited structure of PDB entry 3o44 contains 14 copies of Pfam domain PF16458 (Beta-prism lectin) in Hemolysin. Showing 1 copy in chain A.

PF07968
Domain description: Leukocidin/Hemolysin toxin family
Occurring in:
  1. Hemolysin
The deposited structure of PDB entry 3o44 contains 14 copies of Pfam domain PF07968 (Leukocidin/Hemolysin toxin family) in Hemolysin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000772
Domain description: Ricin B, lectin domain
Occurring in:
  1. Hemolysin
IPR032496
Domain description: Hemolysin, beta-prism lectin
Occurring in:
  1. Hemolysin
IPR036404
Domain description: Jacalin-like lectin domain superfamily
Occurring in:
  1. Hemolysin
IPR035992
Domain description: Ricin B-like lectins
Occurring in:
  1. Hemolysin
IPR044883
Domain description: Hemolysin, pre-stem domain
Occurring in:
  1. Hemolysin
IPR036435
Domain description: Leukocidin/porin MspA superfamily
Occurring in:
  1. Hemolysin
IPR016183
Domain description: Leukocidin/Hemolysin toxin
Occurring in:
  1. Hemolysin
IPR022220
Domain description: Hemolytic toxin, N-terminal
Occurring in:
  1. Hemolysin

Structure domains

CATH CATH domains
2.70.240.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Leukocidin-like
Homology: Leukocidin/porin MspA
Occurring in:
  1. Hemolysin
The deposited structure of PDB entry 3o44 contains 14 copies of CATH domain 2.70.240.10 (Leukocidin-like) in Hemolysin. Showing 1 copy in chain A.
2.100.10.30
Class: Mainly Beta
Architecture: Aligned Prism
Topology: Vitelline Membrane Outer Layer Protein I, subunit A
Homology: Jacalin-like lectin domain
Occurring in:
  1. Hemolysin
The deposited structure of PDB entry 3o44 contains 14 copies of CATH domain 2.100.10.30 (Vitelline Membrane Outer Layer Protein I, subunit A) in Hemolysin. Showing 1 copy in chain A.
2.80.10.50
Class: Mainly Beta
Architecture: Trefoil
Topology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Homology: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Occurring in:
  1. Hemolysin
The deposited structure of PDB entry 3o44 contains 14 copies of CATH domain 2.80.10.50 (Trefoil (Acidic Fibroblast Growth Factor, subunit A)) in Hemolysin. Showing 1 copy in chain A.
6.20.40.20
Class: Special
Architecture: Other non-globular
Topology: Porin MspA ribbon fold
Homology: Leukocidin/Hemolysin toxin, pre-stem domain
Occurring in:
  1. Hemolysin
The deposited structure of PDB entry 3o44 contains 14 copies of CATH domain 6.20.40.20 (Porin MspA ribbon fold) in Hemolysin. Showing 1 copy in chain A.

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