› 3o3z

X-ray diffraction
2.6Å resolution

Complex of a chimeric alpha/beta-peptide based on the gp41 CHR domain bound to a gp41 NHR domain peptide

Released:
DOI: 10.2210/pdb3o3z/pdb
PDB entry 3o3z coloured by chain, front view.
PDB entry 3o3z coloured by chain, side view.
PDB entry 3o3z coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Broad distribution of energetically important contacts across an extended protein interface.
Johnson LM, Horne WS, Gellman SH
J Am Chem Soc 133 10038-41 (2011)
PMID: 21644542

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163836 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.15 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q9YP39 (Residues: 554-589; Coverage: 4%)
Gene name: env
chimeric alpha/beta peptide based on gp41 CHR domain sequence Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.5 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
2 modified residues:
Ligand B3T 1 x B3T
Ligand B3E 1 x B3E

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P4132
Unit cell:
a: 85.804Å b: 85.804Å c: 85.804Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.241 0.302
Expression system: Not provided

Quick links

Citations

3 review citations

Protease-resistant peptide design-empowering nature's fragile warriors against HIV.
Weinstock et al. (2012)
2 more

2 mentions without citation

Broad distribution of energetically important contacts across an extended protein interface.
Johnson et al. (2011)
1 more