› 3o23

X-ray diffraction
2.1Å resolution

Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor

Released:
DOI: 10.2210/pdb3o23/pdb
PDB entry 3o23 coloured by chain, front view.
PDB entry 3o23 coloured by chain, side view.
PDB entry 3o23 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: advantages in comparison with competitive inhibitors.
Lesuisse D, Mauger J, Nemecek C, Maignan S, Boiziau J, Harlow G, Hittinger A, Ruf S, Strobel H, Nair A, Ritter K, Malleron JL, Dagallier A, El-Ahmad Y, Guilloteau JP, Guizani H, Bouchard H, Venot C
Bioorg Med Chem Lett 21 2224-8 (2011)
PMID: 21441024

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08069 (Residues: 982-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MQY 1 x MQY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 49.768Å b: 48.755Å c: 70.73Å
α: 90° β: 98.74° γ: 90°
R-values:
R R work R free
0.238 0.238 0.278
Expression system: Escherichia coli

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Citations

1 review citation

Comprehensive review in current developments of imidazole-based medicinal chemistry.
Zhang et al. (2014)
4 other articles

6 mentions without citation

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