› 3o19

X-ray diffraction
1.66Å resolution

Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid

Released:
DOI: 10.2210/pdb3o19/pdb
PDB entry 3o19 coloured by chain, front view.
PDB entry 3o19 coloured by chain, side view.
PDB entry 3o19 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhou Y, Shaw N, Li Y, Zhao Y, Zhang R, Liu Z-J

Function and Biology Details

Reaction catalysed: 
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin-H2 D-isomerase Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41222 (Residues: 29-190; Coverage: 96%)
Gene names: PDS, PTGDS
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand OLA 1 x OLA
Ligand PLM 1 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6122
Unit cell:
a: 60.512Å b: 60.512Å c: 177.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.175 0.244
Expression system: Escherichia coli

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