3o17 Summary

pdbe.org/3o17
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Crystal Structure of JNK1-alpha1 isoform

The structure was published by Comess, K.M., Sun, C., Abad-Zapatero, C., et al., Marcotte, D., Burns, D.J., and Hajduk, P.J., in in a paper entitled "Crystal Structure of JNK1-alpha1 isoform" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mitogen-activated protein kinase 8 and C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 8 P45983 (1-364) (MK08_HUMAN)search Homo sapienssearch < 90% 370 96%
B Mitogen-activated protein kinase 8 P45983 (1-364) (MK08_HUMAN)search Homo sapienssearch < 90% 370 96%
F C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE Q9WVI9 (154-163) (JIP1_MOUSE)search Mus musculussearch < 90% 10 100%
G C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE Q9WVI9 (154-163) (JIP1_MOUSE)search Mus musculussearch < 90% 10 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P45983 (1 - 364) Mitogen-activated protein kinase 8 Homo sapiens
Q9WVI9 (154 - 163) C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
F, G

Chain ID Molecular function (GO) Biological process (GO)
A, B (P45983) ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch
F, G