› 3o17

X-ray diffraction
3Å resolution

Crystal Structure of JNK1-alpha1 isoform

Released:
DOI: 10.2210/pdb3o17/pdb
PDB entry 3o17 coloured by chain, front view.
PDB entry 3o17 coloured by chain, side view.
PDB entry 3o17 coloured by chain, top view.
Source organisms:
Entry author: Abad-Zapatero C

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-155387 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 42.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45983 (Residues: 1-364; Coverage: 85%)
Gene names: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
Sequence domains: Protein kinase domain
Structure domains:
C-Jun-amino-terminal kinase-interacting protein 1 Chains: F, G
Molecule details ›
Chains: F, G
Length: 10 amino acids
Theoretical weight: 1.19 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q9WVI9 (Residues: 154-163; Coverage: 1%)
Gene names: Ib1, Jip1, Mapk8ip, Mapk8ip1, Prkm8ip

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3221
Unit cell:
a: 155.85Å b: 155.85Å c: 124.492Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.263 0.263 0.308
Expression systems:
  • Escherichia coli
  • Not provided

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