Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase
The structure was published by Staben, S.T., Heffron, T.P., Sutherlin, D.P., et al., Wiesmann, C., Wu, P., and Zhu, B.Y., in 2010 in a paper entitled "Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. This molecule has the UniProt identifier P48736 (PK3CG_HUMAN). The sample contained 954 residues which is < 90% of the natural sequence. Out of 954 residues 826 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: