› 3nv5

X-ray diffraction
2.41Å resolution

Crystal Structure of Cytochrome P450 CYP101D2

Released:
DOI: 10.2210/pdb3nv5/pdb
PDB entry 3nv5 coloured by chain, front view.
PDB entry 3nv5 coloured by chain, side view.
PDB entry 3nv5 coloured by chain, top view.
Source organism: Novosphingobium aromaticivorans DSM 12444
Primary publication:
The structure of CYP101D2 unveils a potential path for substrate entry into the active site.
Yang W, Bell SG, Wang H, Zhou W, Bartlam M, Wong LL, Rao Z
Biochem J 433 85-93 (2011)
PMID: 20950270

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173566 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 50.8 KDa
Source organism: Novosphingobium aromaticivorans DSM 12444
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2G8A2 (Residues: 2-417; Coverage: 100%)
Gene name: Saro_1478
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:
Ligand HEM 1 x HEM
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3221
Unit cell:
a: 86.653Å b: 86.653Å c: 124.705Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.196 0.26
Expression system: Escherichia coli

Quick links

Citations

2 review citations

A novel type of allosteric regulation: functional cooperativity in monomeric proteins.
Denisov et al. (2012)
1 more

4 mentions without citation

Higher order organization of human placental aromatase.
Ghosh et al. (2011)
3 more