phosphoinositide-dependent kinase-1 (PDK1) with fragment8
The structure was published by Medina, J.R., Blackledge, C.W., Heerding, D.A., et al., Briand, J., Wright, L., and Axten, J.M., in 2010 in a paper entitled "Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of phosphoinositide-dependent kinase-1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN). The sample contained 286 residues which is < 90% of the natural sequence. Out of 286 residues 274 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: