3nt1 Summary


High resolution structure of naproxen:COX-2 complex.

The structure was published by Duggan, K.C., Walters, M.J., Musee, J., et al., Kiefer, J.R., Oates, J.A., and Marnett, L.J., in 2010 in a paper entitled "Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.73 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin-endoperoxide synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin-endoperoxide synthase 2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B Prostaglandin-endoperoxide synthase 2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) Prostaglandin-endoperoxide synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) prostaglandin biosynthetic processsearch angiogenesissearch lipid metabolic processsearch fatty acid metabolic processsearch fatty acid biosynthetic processsearch prostaglandin metabolic processsearch inflammatory responsesearch response to oxidative stresssearch embryo implantationsearch learningsearch memorysearch regulation of blood pressuresearch positive regulation of cell proliferationsearch negative regulation of cell proliferationsearch response to radiationsearch response to fructosesearch response to organic substancesearch response to manganese ionsearch response to lithium ionsearch response to organonitrogen compoundsearch positive regulation vascular endothelial growth factor productionsearch positive regulation of cell deathsearch response to organic cyclic compoundsearch sensory perception of painsearch cyclooxygenase pathwaysearch keratinocyte differentiationsearch bone mineralizationsearch ovulationsearch positive regulation of fever generationsearch positive regulation of synaptic plasticitysearch negative regulation of synaptic transmission, dopaminergicsearch response to estradiolsearch response to lipopolysaccharidesearch response to vitamin Dsearch response to cytokinesearch response to tumor necrosis factorsearch cellular response to UVsearch maintenance of blood-brain barriersearch regulation of cell proliferationsearch positive regulation of NF-kappaB import into nucleussearch response to drugsearch hair cyclesearch positive regulation of apoptotic processsearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of cell cyclesearch positive regulation of vasoconstrictionsearch negative regulation of smooth muscle contractionsearch positive regulation of smooth muscle contractionsearch decidualizationsearch positive regulation of smooth muscle cell proliferationsearch brown fat cell differentiationsearch response to glucocorticoidsearch negative regulation of calcium ion transportsearch positive regulation of synaptic transmission, glutamatergicsearch oxidation-reduction processsearch response to fatty acidsearch cellular response to mechanical stimulussearch cellular response to ATPsearch cellular response to hypoxiasearch cellular response to fluid shear stresssearch positive regulation of transforming growth factor beta productionsearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of fibroblast growth factor productionsearch positive regulation of brown fat cell differentiationsearch positive regulation of platelet-derived growth factor productionsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch lipid bindingsearch oxidoreductase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch enzyme bindingsearch heme bindingsearch protein homodimerization activitysearch metal ion bindingsearch dioxygenase activitysearch cytoplasmsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch caveolasearch membranesearch organelle membranesearch neuron projectionsearch intracellular membrane-bounded organellesearch protein complexsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search