3npc Summary

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Crystal structure of JNK2 complexed with BIRB796

The structure was published by Kuglstatter, A., Ghate, M., Tsing, S., et al., Shaw, D., Barnett, J.W., and Browner, M.F., in 2010 in a paper entitled "X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 9.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 9 P45984 (1-364) (MK09_HUMAN)search Homo sapienssearch < 90% 364 98%
B Mitogen-activated protein kinase 9 P45984 (1-364) (MK09_HUMAN)search Homo sapienssearch < 90% 364 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P45984 (1 - 364) Mitogen-activated protein kinase 9 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P45984) protein kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch