3npc Summary


Crystal structure of JNK2 complexed with BIRB796

The structure was published by Kuglstatter, A., Ghate, M., Tsing, S., et al., Shaw, D., Barnett, J.W., and Browner, M.F., in 2010 in a paper entitled "X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 9.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 9 P45984 (1-364) (MK09_HUMAN)search Homo sapienssearch < 90% 364 98%
B Mitogen-activated protein kinase 9 P45984 (1-364) (MK09_HUMAN)search Homo sapienssearch < 90% 364 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P45984 (1 - 364) Mitogen-activated protein kinase 9 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P45984) protein kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch