3nos Summary



The structure was published by Fischmann, T.O., Hruza, A., Niu, X.D., et al., Lundell, D.J., Narula, S.K., and Weber, P.C., in 1999 in a paper entitled "Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ENDOTHELIAL NITRIC-OXIDE SYNTHASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENDOTHELIAL NITRIC-OXIDE SYNTHASE P29474 (66-492) (NOS3_HUMAN)search Homo sapienssearch < 90% 427 93%
B ENDOTHELIAL NITRIC-OXIDE SYNTHASE P29474 (66-492) (NOS3_HUMAN)search Homo sapienssearch < 90% 427 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29474 (66 - 492) ENDOTHELIAL NITRIC-OXIDE SYNTHASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nitric oxide (NO) synthase oxygenase domainsearch Nitric Oxide Synthase; Chain A, domain 1search, Nitric Oxide Synthase;Heme Domain;Chain A domain 2search, Nitric Oxide Synthase; Chain A, domain 3search Nitric oxide synthase, oxygenase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P29474) nitric oxide biosynthetic processsearch oxidation-reduction processsearch nitric-oxide synthase activitysearch

Chain InterPro annotation
A, B Nitric oxide synthase, N-terminalsearch