3nos Summary

pdbe.org/3nos
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH ARGININE SUBSTRATE

The structure was published by Fischmann, T.O., Hruza, A., Niu, X.D., et al., Lundell, D.J., Narula, S.K., and Weber, P.C., in 1999 in a paper entitled "Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ENDOTHELIAL NITRIC-OXIDE SYNTHASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENDOTHELIAL NITRIC-OXIDE SYNTHASE P29474 (66-492) (NOS3_HUMAN)search Homo sapienssearch < 90% 427 93%
B ENDOTHELIAL NITRIC-OXIDE SYNTHASE P29474 (66-492) (NOS3_HUMAN)search Homo sapienssearch < 90% 427 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29474 (66 - 492) ENDOTHELIAL NITRIC-OXIDE SYNTHASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nitric oxide (NO) synthase oxygenase domainsearch Nitric Oxide Synthase; Chain A, domain 1search, Nitric Oxide Synthase;Heme Domain;Chain A domain 2search, Nitric Oxide Synthase; Chain A, domain 3search Nitric oxide synthase, oxygenase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P29474) nitric oxide biosynthetic processsearch oxidation-reduction processsearch nitric-oxide synthase activitysearch

Chain InterPro annotation
A, B Nitric oxide synthase, N-terminalsearch