3nko Summary

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Crystal structure of mouse autotaxin in complex with 16:0-LPA

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Nishimasu, H., Okudaira, S., Hama, K., et al., Takagi, J., Aoki, J., and Nureki, O., in 2011 in a paper entitled "Crystal structure of autotaxin and insight into GPCR activation by lipid mediators" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. This molecule has the UniProt identifier Q9R1E6 (ENPP2_MOUSE)search. The sample contained 831 residues which is 99% of the natural sequence. Out of 831 residues 772 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 (36-862) (ENPP2_MOUSE)search Mus musculussearch 99% 831 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9R1E6 (36 - 862) Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Mus musculus

Chain Sequence family (Pfam)
A (Q9R1E6) PF01033: Somatomedin B domainsearch, PF01223: DNA/RNA non-specific endonucleasesearch, PF01663: Type I phosphodiesterase / nucleotide pyrophosphatasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q9R1E6) catalytic activitysearch hydrolase activitysearch scavenger receptor activitysearch polysaccharide bindingsearch metal ion bindingsearch nucleic acid bindingsearch zinc ion bindingsearch lysophospholipase activitysearch calcium ion bindingsearch phosphodiesterase I activitysearch alkylglycerophosphoethanolamine phosphodiesterase activitysearch nucleotide diphosphatase activitysearch immune responsesearch metabolic processsearch lipid metabolic processsearch chemotaxissearch receptor-mediated endocytosissearch phospholipid catabolic processsearch phosphatidylcholine catabolic processsearch regulation of cell migrationsearch lipid catabolic processsearch nucleic acid phosphodiester bond hydrolysissearch extracellular regionsearch extracellular spacesearch integral component of plasma membranesearch

Chain InterPro annotation
A Somatomedin B domainsearch DNA/RNA non-specific endonucleasesearch Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Somatomedin B, chordatasearch Extracellular Endonuclease, subunit Asearch Ectonucleotide pyrophosphatase/phosphodiesterase familysearch