3njp Summary


The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling

The structure was published by Lu, C., Mi, L.Z., Grey, M.J., et al., Graef, E., Yokoyama, S., and Springer, T.A., in 2010 in a paper entitled "Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.304 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Epidermal growth factor receptor and Epidermal growth factor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal growth factor receptor P00533 (25-638) (EGFR_HUMAN)search Homo sapienssearch < 90% 614 100%
B Epidermal growth factor receptor P00533 (25-638) (EGFR_HUMAN)search Homo sapienssearch < 90% 614 100%
C Epidermal growth factor P01133 (975-1021) (EGF_HUMAN)search Homo sapienssearch < 90% 47 100%
D Epidermal growth factor P01133 (975-1021) (EGF_HUMAN)search Homo sapienssearch < 90% 47 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00533 (25 - 638) Epidermal growth factor receptor Homo sapiens
P01133 (975 - 1021) Epidermal growth factor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
C, D Lamininsearch EGF-like domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P00533) membranesearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch

Chain InterPro annotation
A, B Receptor L-domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
C, D Epidermal growth factor-like domainsearch EGF-like, conserved sitesearch Epidermal growth factor receptor ligandsearch