3nj9 Summary


Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor

A publication describing this structure is not available. The depositing authors are Temperini, C.search; Cecchi, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) response to estrogensearch secretionsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch kidney developmentsearch regulation of anion transportsearch response to pHsearch one-carbon metabolic processsearch regulation of chloride transportsearch bicarbonate transportsearch regulation of intracellular pHsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch response to zinc ionsearch cytosolsearch extracellular vesicular exosomesearch myelin sheathsearch cytoplasmsearch axonsearch plasma membranesearch apical part of cellsearch membranesearch microvillussearch extracellular spacesearch basolateral plasma membranesearch lyase activitysearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch