3nfp Summary

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Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain

The structure was published by Yang, H., Wang, J., Du, J., et al., Guo, H., Guo, Y., and Ding, J., in 2010 in a paper entitled "Structural basis of immunosuppression by the therapeutic antibody daclizumab" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.86 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab, and Interleukin-2 receptor subunit alpha.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Heavy chain of Fab fragment of daclizumab Not available
Homo sapienssearch Not available 216 99%
H Heavy chain of Fab fragment of daclizumab Not available
Homo sapienssearch Not available 216 99%
B Light chain of Fab fragment of daclizumab Not available
Homo sapienssearch Not available 212 100%
L Light chain of Fab fragment of daclizumab Not available
Homo sapienssearch Not available 212 100%
I Interleukin-2 receptor subunit alpha P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 223 55%
K Interleukin-2 receptor subunit alpha P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 223 55%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01589 (22 - 238) Interleukin-2 receptor subunit alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, H Immunoglobulinssearch
B, L Immunoglobulinssearch
I, K Complement Module, domain 1search Sushi domain (SCR repeat)search
Chain InterPro annotation
A, H Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B, L Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
I, K Sushi/SCR/CCP domainsearch Interleukin-2 receptor alphasearch