3nb5 Summary


Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide

The structure was published by Davis, R.A., Hofmann, A., Osman, A., et al., Innocenti, A., Supuran, C.T., and Poulsen, S.A., in 2011 in a paper entitled "Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch response to steroid hormonesearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch positive regulation of bone resorptionsearch response to zinc ionsearch response to pHsearch kidney developmentsearch response to organic substancesearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch secretionsearch positive regulation of osteoclast differentiationsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch response to estrogensearch small molecule metabolic processsearch membranesearch cytoplasmsearch extracellular vesicular exosomesearch basolateral plasma membranesearch cytosolsearch axonsearch apical part of cellsearch plasma membranesearch myelin sheathsearch microvillussearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch