3n9y Summary


Crystal structure of human CYP11A1 in complex with cholesterol

The structure was published by Strushkevich, N., Mackenzie, F., Cherkesova, T., Grabovec, I., Usanov, S., and Park, H.W., in 2011 in a paper entitled "Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cholesterol side-chain cleavage enzyme and Adrenodoxin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cholesterol side-chain cleavage enzyme P05108 (41-521) (CP11A_HUMAN)search Homo sapienssearch 90% 487 96%
B Cholesterol side-chain cleavage enzyme P05108 (41-521) (CP11A_HUMAN)search Homo sapienssearch 90% 487 96%
C Adrenodoxin P10109 (62-175) (ADX_HUMAN)search Homo sapienssearch < 90% 114 59%
D Adrenodoxin P10109 (62-175) (ADX_HUMAN)search Homo sapienssearch < 90% 114 59%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P05108 (41 - 521) Cholesterol side-chain cleavage enzyme Homo sapiens
P10109 (62 - 175) Adrenodoxin Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P05108) Cytochrome p450search PF00067: Cytochrome P450search
C, D 2Fe-2S iron-sulfur cluster binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05108) response to acid chemicalsearch organic acid metabolic processsearch lipid metabolic processsearch steroid biosynthetic processsearch C21-steroid hormone biosynthetic processsearch progesterone biosynthetic processsearch estrogen biosynthetic processsearch xenobiotic metabolic processsearch response to nutrientsearch mating behaviorsearch steroid metabolic processsearch cholesterol metabolic processsearch C21-steroid hormone metabolic processsearch male gonad developmentsearch response to salt stresssearch response to organic substancesearch response to ionizing radiationsearch response to gamma radiationsearch Schwann cell differentiationsearch response to organic cyclic compoundsearch sterol metabolic processsearch response to insecticidesearch biphenyl metabolic processsearch dibenzo-p-dioxin metabolic processsearch phenol-containing compound metabolic processsearch phthalate metabolic processsearch cerebellum developmentsearch hippocampus developmentsearch response to vitamin Esearch Leydig cell differentiationsearch response to L-ascorbic acidsearch response to genisteinsearch response to gonadotropinsearch vitamin D metabolic processsearch response to drugsearch response to hydrogen peroxidesearch response to alkaloidsearch response to peptide hormonesearch response to estrogensearch small molecule metabolic processsearch cellular response to fibroblast growth factor stimulussearch response to antibioticsearch response to cadmium ionsearch response to steroid hormonesearch fractalkine metabolic processsearch response to corticosteronesearch response to cAMPsearch oxidation-reduction processsearch granulosa cell differentiationsearch maternal process involved in female pregnancysearch response to fungicidesearch testosterone biosynthetic processsearch cellular response to lipopolysaccharidesearch cellular response to antibioticsearch cellular response to cadmium ionsearch cellular response to cAMPsearch cellular response to interleukin-1search cellular response to tumor necrosis factorsearch cellular response to gonadotropin stimulussearch cellular response to follicle-stimulating hormone stimulussearch cellular response to peptide hormone stimulussearch cellular response to transforming growth factor beta stimulussearch monooxygenase activitysearch iron ion bindingsearch cholesterol monooxygenase (side-chain-cleaving) activitysearch cholesterol bindingsearch oxidoreductase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch heme bindingsearch metal ion bindingsearch mitochondrionsearch mitochondrial inner membranesearch mitochondrial matrixsearch membranesearch mitochondrial cristasearch perikaryonsearch
C, D (P10109) electron carrier activitysearch iron-sulfur cluster bindingsearch 2 iron, 2 sulfur cluster bindingsearch

Chain InterPro annotation
A, B Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch
C, D 2Fe-2S ferredoxin-type domainsearch Adrenodoxinsearch Beta-grasp domainsearch Adrenodoxin, iron-sulphur binding sitesearch