3n8z Summary


Crystal Structure of Cyclooxygenase-1 in Complex with Flurbiprofen

The structure was published by Sidhu, R.S., Lee, J.Y., Yuan, C., and Smith, W.L., in 2010 in a paper entitled "Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%
B Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (32 - 584) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05979) prostaglandin biosynthetic processsearch lipid metabolic processsearch fatty acid metabolic processsearch fatty acid biosynthetic processsearch prostaglandin metabolic processsearch inflammatory responsesearch response to oxidative stresssearch regulation of blood pressuresearch cyclooxygenase pathwaysearch oxidation-reduction processsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch oxidoreductase activitysearch heme bindingsearch metal ion bindingsearch dioxygenase activitysearch nucleussearch cytoplasmsearch endoplasmic reticulumsearch membranesearch integral component of membranesearch intracellular membrane-bounded organellesearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search