3n8z Summary


Crystal Structure of Cyclooxygenase-1 in Complex with Flurbiprofen

The structure was published by Sidhu, R.S., Lee, J.Y., Yuan, C., and Smith, W.L., in 2010 in a paper entitled "Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%
B Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (32 - 584) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P05979) prostaglandin-endoperoxide synthase activitysearch metal ion bindingsearch peroxidase activitysearch oxidoreductase activitysearch dioxygenase activitysearch heme bindingsearch response to oxidative stresssearch prostaglandin biosynthetic processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch fatty acid biosynthetic processsearch regulation of blood pressuresearch oxidation-reduction processsearch lipid metabolic processsearch inflammatory responsesearch cyclooxygenase pathwaysearch intracellular membrane-bounded organellesearch membranesearch endoplasmic reticulumsearch integral component of membranesearch cytoplasmsearch endoplasmic reticulum membranesearch nucleussearch organelle membranesearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search