3n8w Summary

pdbe.org/3n8w
spacer

Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen

The structure was published by Sidhu, R.S., Lee, J.Y., Yuan, C., and Smith, W.L., in 2010 in a paper entitled "Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Prostaglandin G/H synthase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%
B Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (32 - 584) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (CATH) Sequence family (Pfam)
A (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch
B (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P05979) cyclooxygenase pathwaysearch lipid metabolic processsearch inflammatory responsesearch prostaglandin biosynthetic processsearch regulation of blood pressuresearch response to oxidative stresssearch oxidation-reduction processsearch fatty acid biosynthetic processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch endoplasmic reticulum membranesearch nucleussearch cytoplasmsearch endoplasmic reticulumsearch organelle membranesearch intracellular membrane-bounded organellesearch membranesearch integral component of membranesearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch oxidoreductase activitysearch dioxygenase activitysearch
B (P05979) inflammatory responsesearch cyclooxygenase pathwaysearch oxidation-reduction processsearch response to oxidative stresssearch regulation of blood pressuresearch fatty acid biosynthetic processsearch prostaglandin biosynthetic processsearch fatty acid metabolic processsearch prostaglandin metabolic processsearch lipid metabolic processsearch integral component of membranesearch membranesearch endoplasmic reticulumsearch nucleussearch organelle membranesearch cytoplasmsearch intracellular membrane-bounded organellesearch endoplasmic reticulum membranesearch metal ion bindingsearch heme bindingsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch oxidoreductase activitysearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search
B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search