3n8w Summary

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Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen

The structure was published by Sidhu, R.S., Lee, J.Y., Yuan, C., and Smith, W.L., in 2010 in a paper entitled "Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Prostaglandin G/H synthase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%
B Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (32 - 584) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (CATH) Sequence family (Pfam)
A (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch
B (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P05979) inflammatory responsesearch oxidation-reduction processsearch lipid metabolic processsearch prostaglandin biosynthetic processsearch fatty acid metabolic processsearch regulation of blood pressuresearch fatty acid biosynthetic processsearch prostaglandin metabolic processsearch cyclooxygenase pathwaysearch response to oxidative stresssearch oxidoreductase activitysearch metal ion bindingsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch heme bindingsearch nucleussearch cytoplasmsearch intracellular membrane-bounded organellesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch organelle membranesearch membranesearch integral component of membranesearch
B (P05979) cyclooxygenase pathwaysearch prostaglandin biosynthetic processsearch prostaglandin metabolic processsearch oxidation-reduction processsearch regulation of blood pressuresearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch lipid metabolic processsearch inflammatory responsesearch response to oxidative stresssearch prostaglandin-endoperoxide synthase activitysearch oxidoreductase activitysearch heme bindingsearch peroxidase activitysearch dioxygenase activitysearch metal ion bindingsearch membranesearch nucleussearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch integral component of membranesearch endoplasmic reticulumsearch cytoplasmsearch organelle membranesearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search
B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search