3n8w Summary

pdbe.org/3n8w
spacer

Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen

The structure was published by Sidhu, R.S., Lee, J.Y., Yuan, C., and Smith, W.L., in 2010 in a paper entitled "Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Prostaglandin G/H synthase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%
B Prostaglandin G/H synthase 1 P05979 (32-584) (PGH1_SHEEP)search Ovis ariessearch 96% 553 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (32 - 584) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (CATH) Sequence family (Pfam)
A (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch
B (P05979) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P05979) prostaglandin biosynthetic processsearch prostaglandin metabolic processsearch oxidation-reduction processsearch fatty acid metabolic processsearch regulation of blood pressuresearch fatty acid biosynthetic processsearch response to oxidative stresssearch lipid metabolic processsearch cyclooxygenase pathwaysearch inflammatory responsesearch cytoplasmsearch integral component of membranesearch organelle membranesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch membranesearch nucleussearch dioxygenase activitysearch metal ion bindingsearch prostaglandin-endoperoxide synthase activitysearch oxidoreductase activitysearch peroxidase activitysearch heme bindingsearch
B (P05979) cyclooxygenase pathwaysearch lipid metabolic processsearch oxidation-reduction processsearch fatty acid metabolic processsearch prostaglandin biosynthetic processsearch prostaglandin metabolic processsearch fatty acid biosynthetic processsearch inflammatory responsesearch regulation of blood pressuresearch response to oxidative stresssearch membranesearch nucleussearch cytoplasmsearch intracellular membrane-bounded organellesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch organelle membranesearch integral component of membranesearch prostaglandin-endoperoxide synthase activitysearch peroxidase activitysearch dioxygenase activitysearch metal ion bindingsearch oxidoreductase activitysearch heme bindingsearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search
B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search